USD - Biology 482 - Horwitz et al. 2007

Papers related to Horwitz et al. 2007

Presentation/discussion paper: Horwitz et al. 2007. A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase

See also BRCA gene patents information

(These typically provide much more information than you need to help you understand the Horwitz paper - you may find the abstract, introduction and/or a particular figure or table will be most helpful.)

Reviews:

Hershko & Ciechanover, 1999. The Ubiquitin system
Jackson et al., 2000. The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases
Mondal & Parvin, 1999. BRCA1 function in transcription
Thomas & Chiang, 2006. The General transcription machinery and general cofactors
[ref 3] Turner et al., 2004. Hallmarks of 'BRCAness' in sporadic cancers

The original BRCA1 cloning paper:

[ref 1] Miki et al., 1994. A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1.
Note the number of authors. Cloning human genes was REALLY difficult in the 1980-90's, involving an enormous effort by many scientists.

Primary literature papers many are referenced by Horwitz et al., 2007 (or otherwise useful/related):

Chiba & Parvin, 2001. Redistribution of BRCA1 among Four Different Protein Complexes following Replication Blockage
Chiba & Parvin, 2002. The BRCA1 and BARD1 Association with the RNA Polymerase II Holoenzyme
[ref 40] Haile & Parvin, 1999. Activation of Transcription in Vitro by the BRCA1 Carboxyl-terminal Domain
[ref 9] Horwitz et al., 2006. Direct Stimulation of Transcription Initiation by BRCA1 Requires Both Its Amino and Carboxyl Termini
[ref 11] Kleiman et al., 2005. BRCA1/BARD1 inhibition of mRNA 3′ processing involves targeted degradation of RNA polymerase II
Krum et al., 2003. BRCA1 Associates with Processive RNA Polymerase II
[ref 42] Schlegel et al., 2000. BRCA1 interaction with RNA polymerase II reveals a role for hRPB2 and hRPB10a in activated transcription.
[ref 43] Starita et al., 2004. BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number
[ref 10] Starita et al., 2005. BRCA1/BARD1 Ubiquitinate Phosphorylated RNA Polymerase II
[ref 46] Sui et al., 2002. A DNA vector-based RNAi technology to suppress gene expression in mammalian cells