Joseph Provost 
Chem/Bio 332 Biochemistry II
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UPDATED SYLLABUS (March 2023) Office Hours Mon 10:00; Tues 4:00, Wed 3:30; Thurs apt; Fri 11:15. Office hours will be in person. Scroll to the bottom of this page for assignments and other links!!!! |
Class Notes |
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Suggested Readings, Handouts & Chapter Questions |
Study Help and Links |
17 (1-4) 18 16(1-3) |
1, 2, 4, 5, 9, 10, 16, 20, 28, 29
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| Lipid Metabolism I | 20 (1,6,7) | 2, 5, 7, 8, 11, 15, 16, 20, 33, 38 |
Lipid LO |
| Lipid Metabolism II | 20 (2-5) | 1, 5, 6, 10, 11, 19, 29, 34, 37 |
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| Metabolic Integration | 22 |
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Metabolic Integ LO |
| Cell Signaling (I) (2) (3) | 13 (1 is review, 2-4 required) | Kobilka GPCR, Molec Signal GPCR,Hamm G Prot, Newton PKC,PKC Review |
Cell Signaling LO
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| DNA/RNA Protein Binding and Repair | 24(4) |
Supplimental Reading (not a paper) not required but helpful! |
DNA Binding LO |
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25(4)
Drug Design Review (1) (2) and Link (1) (2) (3)
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DNA Repair LO |
| Biochemistry of Cancer (1) (2) (3) (4) | 22(3D), Box 13-3, 28(4 A-C) |
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Biochem of Cancer LO |
| Homework: | |
General Instructions for Paper Review
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PEPCK Paper Assignment/Activity Optional - How To Read Papers Handout Optional - Mind Map / How to read a figure Required Pre-Class Assignment (bring filled out assignment to class: 5 points) Required - Group Self-Assessment (turn in for each team member. Hard copies will be given in class: 5 points)
PEPCK Activity. Read your group's assigned paper prior to class and fill out the required pre-classassignment. Each group will work together for the first 20-30 min of class to prepare a flash presentation of their paper. The main purpose and the hypothesis. Each group will then present 1-3 slides of data followed by a conclusion with a WDIC moment (Why Do I Care). No more than ten min per presentation. 40 points.
1(Cordova, Fagen, Johnson, Lyons, Pulido, Tarbox )PEPCK-M expression in mouse liver potentialtes, not replaces, PEPCK-C mediated gluconeo 2(Giles, Muahay, Narasimhan, Sevilla, Miller, Riley ) A role for mitochondrial PEPCK in regulation of hepatic gluconeogenesis 3 (Bidwell Astaburuaga, Ziomek, Dempsey, Heras, Zhou ) two papers. Prepare a single presention as a combination of the two related papers. PEPCK Super Mouse and PEPCK in Muscle |
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Signal Transduction Paper Assignment: Review the following paper and Pick ONE of the review papers on signaling and cancer. Protein Phosphatases: From Cancer to Small Molecules Understanding the Physical Basis of Memory Emerging Roles of Epigenetic Regulation in Obesity and Metabolic Disease New Stratagies for Targeting Kinase Networks in Cancer Therapeutic Potential of Inhibiting PPAR to Treat Diabetes Role of PLC in Immunological disorders, cancer, and neurodegeneration Regulation of Wnt Receptor: Implications for Colon Cancer The Many Lives of MYC in the Pancreatic b-Cell Ligand Bias in Tyrosine Kinase Receptors Metabolite Sensing and Signalng in Cancer
As a group 1) Write an overview paragraph on the review. Include examples supporting any statements. 2) Each review has majors sections/topics/headings - for each section, identify the key point of the section (aka what is described in the header) and describe the information that supports the statement.
No minimum lenght or maximum lenght - write to understand and communicate this to your professor!
3) Students will work in groups on the paper/review of interest and present a ten min overview of their paper and submit a group assignment
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| VV&P Guided Exploration Links | Cancer/Signal Review Paper Options 1) Cisplatin first metal based anticancer drug |